J. Justin McCormick
Associate Dean of Research and Graduate Studies, College of Osteopathic Medicine
St. Paul's College, B.S., 1957
St. Paul's College, M.A., 1960
Catholic University, M.S., biology, 1963
Catholic University, Ph.D., cell physiology, 1967 ?
Dr. McCormick's research is directed at understanding genetic changes at the molecular level that are involved in the transformation of normal human cells into cancer cells. By gaining insight into the mechanisms, strategies can be developed to interrupt or thwart this transformation. His research, which is closely related to his colleague Veronica Maher's work, concentrates defining the specific genetic changes required to transform normal human cells into malignant tumor cells and to determine the mechanisms by which environmental chemical carcinogens and radiation bring about such changes. He studies the nature of the mutations involved, as well as the preventative role of DNA repair. His team has developed a unique lineage of human fibroblast cell strains, clonally derived, one from the other, beginning with normal diploid cells, and moving step-by-step to fully malignant cells able to form tumors in suitable animal hosts. Dr. McCormick's research interests related to toxicology fall under the broad umbrella of biochemical toxicology and include cytotoxic, mutagenic and transforming effects.