Previous Postdoctoral Researchers
Radin joined the DellaPenna lab at MSU in October 2011 to continue research on isoprenoid derived compounds in plants, a structurally and functionally extremely diverse group of natural products. Her research involved the use of molecular biology, enzymology and (bio)chemical analytics in order to identify and characterize enzymes which influence the biosynthesis of these valuable natural products. Radin joined the Hamberger lab in 2016.
Studies in the DellaPenna lab have shown that tocopherols, which are synthesized in plastids, can affect the composition of polyunsaturated fatty acid content of ER lipids. Payam’s goal was to better understand such extraplastidic functions of tocopherols by combining various Arabidopsis tocopherol biosynthesis mutants using molecular, genetic and analytical approaches. Payam tested for interactions between the plastid and ER to see whether there is a direct metabolic exchange between these compartments. Payam is now a Postdoctoral Research Associate at the Department of Plant Sciences, University of Cambridge.
Historically, the enzymes involved in the carotenoid and tocopherol biosynthetic pathway have been identified through biochemistry and genetics. To further understand the genetics of seed carotenoids and tocopherols in plants, employed a multi-disciplinary approach involving genetics, molecular, and computational biology. Through the use of Genome Wide Association (GWA) studies, Sabrina aimed to uncover novel non-biosynthetic genes that regulate the genetic architecture of carotenoids and tocopherols in Arabidopsis seeds. In addition, Sabrina used natural variation in Arabidopsis to dissect genes involved in iron bioavailability and content in plants. Her project was funded by the Bill and Melinda Gates foundation with the aim to tackle the most common nutritional deficiency, namely iron, that ails both developed and developing countries. Sabrina is now a Postdoctoral Research Associate at the Department of Plant Sciences, University of Cambridge.
Ruthie’s main objective was to enhance our fundamental knowledge of the polygenic nature of amino acid related traits in plants by performing Genome Wide Association Studies (GWAS) and candidate gene association analysis for traits in both Arabidopsis and Maize dry seeds. The knowledge obtained has provided a unique opportunity to compare the genetic architecture of a complex trait for primary metabolism in a selfing plant not subject to artificial selection (Arabidopsis) and an out crossing plant that has been extensively selected by humans for food (maize). Ruthie is now an Assistant Professor in the Division of Biological Sciences, University of Missouri.
Obtained his Ph.D. degree at the University of Freiburg (Germany) under the supervision of Prof. Dr. Peter Beyer and joined Dr. DellaPenna's laboratory in July 2010. His doctoral project was aimed at enhancing the provitamin A content of Cassava root by genetic modification. Jacobo's work demonstrated that phytoene synthase activity was the rate-limiting step in the carotenoid biosynthetic pathway in Cassava roots and that a naturally occurring point mutation in the gene is responsible for lines with white versus yellow roots (carotenoid containing). A second project focused on cloning genes for the activities of the recently reported recycling pathway for oxidized tocopherols.
Eun-Ha Kim received her Ph.D from Australian National University in Australia (2006), where her research focused on structural and functional analysis of thylakoid membranes of higher plants. As a postdoctoral fellow in Dr. DellaPenna's group she has extended her interest in the synthesis and functions of carotenoid to Chlamydomons and Maize. Additionally, she was involved in association mapping approaches in maize seeds to dissect the genetic and molecular basis of carotenoid biosynthesis.
Joined the group of Prof. Dean DellaPenna in 2006 to study the role of tocochromanols in plants. Tocochromanols are a group of amphipathic compounds with a polar head and a hydrophobic side chain that are exclusively synthetized by photosynthetic organisms and include tocopherols, tocotrienols and plastochromanol-8. Most of these compounds exhibit vitamin E activity and are therefore essential nutrients. Laurent’s research focused on the physiological and biochemical characterization of the Arabidopsis tocopherol-deficient vte1 and vte2 mutants. Laurent is now a researcher at the University of Fribourg.
Marina was involved in the Medicinal plant project in Dr. DellaPenna's group. She was focused on establishing the pathway that leads to formation of camptothecin, a anticancer drug produced by the Happy Chinese tree Camptotheca acuminata. She contributed to the expression and metabolite databases using RNA seq technology and metabolite profiling, respectively, of different Camptotheca tissues and mined these resources to identify genes/enzymes involved in the biosynthesis of camptothecin.
Laura Ullrich (Gilliland)
Laura Ullrich Gilliland is now the Manager of the Center for Lignocellulose Strucutre and Formation (CLSF), a DOE Energy Frontier Research Center with the Pennsylvania State University as the lead institution. The CLSF aims to dramatically increase our fundamental knowledge of the formation and physical interactions of bio-polymer networks in plant cell walls in to provide a basis for improved methods for converting biomass into fuels. For more information see http://www.lignocellulose.org/
Scott Sattler is currently a Research Molecular Biologist with the USDA at Lincoln Nebraska and an Adjunct Assistant Professor in the Department of Agronomy and Horticulture at the University of Lincoln, Nebraska. Since leaving the lab Scott's research has focused on understand the biochemical pathways affecting both structural and storage carbohydrate utilization in sorghum for use in bioenergy production systems. His current research focuses on the cloning and characterization of brown midrib mutants in sorghum, whose gene products are involved in cell wall lignification.