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Recent Publications

Yang Y, Gunasekara M, Muhammednazaar S, Li Z, Hong H. “Proteolysis mediated by the membrane-integrated ATP-dependent protease FtsH has a unique nonlinear dependence on ATP hydrolysis rates.” Protein Sci. (2019) Apr 22;. doi: 10.1002/pro.3629

Gaffney KA, Hong H. “The rhomboid protease GlpG has weak interaction energies in its active site hydrogen bond network.” J Gen Physiol. (2018) Nov 12;. doi: 10.1085/jgp.201812047

Shen X, Kou Q, Guo R, Yang Z, Chen D, Liu X, Hong H, Sun L. “Native Proteomics in Discovery Mode Using Size-Exclusion Chromatography-Capillary Zone Electrophoresis-Tandem Mass Spectrometry.” Anal Chem. (2018) Aug 13. doi: 10.1021/acs.analchem.8b02725

Yang Y, Guo R, Gaffney K, Kim M, Muhammednazaar S, Tian W, Wang B, Liang J, Hong H. “Folding-Degradation Relationship of a Membrane Protein Mediated by the Universally Conserved ATP-dependent Protease FtsH.” J Am Chem Soc. (2018) Mar 12. doi: 10.1021/jacs.8b00832

Guo R, Gaffney K, Yang Z, Kim M, Sungsuwan S, Huang X, Hubbell WL, Hong H. “Steric trapping reveals a cooperativity network in the intramembrane protease GlpG.” Nat Chem Biol. (2016) Mar 21;. doi:10.1038/nchembio.2048

Hong H. “Role of Lipids in Folding, Misfolding and Function of IntegralMembrane Proteins.” Adv Exp Med Biol. (2015);855:1-31. doi:10.1007/978-3-319-17344-3_1

Hong, H. “Toward understanding driving forces in membrane protein folding. ” Archives of Biochemistry and Biophysics. (2014) Dec 15;564:297-313. doi:10.1016/

Ghirlanda G, Senes A, Heedeok H, Chang YC, Bowie JU. “Measuring Transmembrane Helix Interaction Strengths in Lipid Bilayers Using Steric Trapping” Methods in Molecular Biology. (2013);1063:37-56. doi:10.1007/978-1-62703-583-5

Hong H, Rinehart D, Tamm LK. “Membrane Depth-Dependent Energetic Contribution of the Tryptophan Side Chain to the Stability of Integral Membrane Proteins.” Biochemistry. (2013) Jun 25;52(25):4413-21. doi:10.1021/bi400344b

Hong H, Bowie JU. “Dramatic Destabilization of Transmembrane Helix Interactions by Features of Natural Membrane Environments.” Journal of the American Chemical Society. (2011) Jul 27;133(29):11389-98. doi:10.1021/ja204524c

Hong H, Blois TM, Cao Z, Bowie JU. “Method to measure strong protein-protein interactions in lipid bilayers using a steric trap.” Proceedings of the National Academy of Sciences. (2010) Nov 16;107(46):19802-7. doi:10.1073/pnas.1010348107

Blois TM, Heedeok H, Kim TH, Bowie JU. “Protein Unfolding with a Steric Trap.” Journal of the American Chemical Society. (2009) Oct 7;131(39):13914-15. doi:10.1021/ja905725n

Hong H, Joh NH, Bowie JU, Tamm LK. “Methods for measuring the thermodynamic stability of membrane proteins.” Methods Enzymol. (2009);455:213-36. doi:10.1016/S0076-6879(08)04208-0

Hong H, Park S, Jiménez RH, Rinehart D, Tamm LK. “Role of Aromatic Side Chains in the Folding and Thermodynamic Stability of Integral Membrane Proteins.” Journal of the American Chemical Society. (2007) Jul 4;129(26):8320-27. doi:10.1021/ja068849o

Hong H, Szabo G, Tamm LK. “Electrostatic couplings in OmpA ion-channel gating suggest a mechanism for pore opening.” Nature Chemical Biology. (2006) Nov;2(11):627-35. doi:10.1038/nchembio827

Hong H. “The Outer Membrane Protein OmpW Forms an Eight-stranded beta-Barrel with a Hydrophobic Channel.” Journal of Biological Chemistry. (2006) Mar 17;281(11):7568-77. doi:10.1074/jbc.M512365200

Tamm LK, Hong H, Liang B. “Folding and assembly of β-barrel membrane proteins.” Biochimica et Biophysica Acta (BBA) - Biomembranes. (2004) Nov 3;1666(1-20):250-63. doi:10.1016/j.bbamem.2004.06.011

Hong H, Tamm LK. “Elastic coupling of integral membrane protein stability to lipid bilayer forces.” Proceedings of the National Academy of Sciences. (2004) Mar 23;101(12):4065-70. doi:10.1073/pnas.0400358101