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Recent Publications

Dornbos P, Jurgelewicz A, Fader KA, Williams K, Zacharewski TR, LaPres JJ. “Characterizing the Role of HMG-CoA Reductase in Aryl Hydrocarbon Receptor-Mediated Liver Injury in C57BL/6 Mice.” Sci Rep. (2019) Nov 1;9(1):15828. doi: 10.1038/s41598-019-52001-2

Dornbos P, Warren M, Crawford RB, Kaminski N, Threadgill DW, LaPres JJ. “Characterizing Serpinb2 as a modulator of TCDD-induced suppression of the B cell.” Chem Res Toxicol. (2018) Oct 19. doi: 10.1021/acs.chemrestox.8b00225

Dornbos P, LaPres JJ. “Incorporating Population-Level Genetic Variability within Laboratory Models in Toxicology: From the Individual to the Population.” Toxicology. (2017) Dec 21;. doi: 10.1016/j.tox.2017.12.007

Dornbos P, Crawford RB, Kaminski NE, Hession SL, LaPres JJ. “The Influence of Human Inter-individual Variability on the Low-dose Region of Dose-Response Curve Induced by 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Primary B Cells.” Toxicol Sci. (2016) Jul 29. pii: kfw128. doi:10.1093/toxsci/kfw128

Hwang HJ, Dornbos P, LaPres JJ. “Data on AHR-dependent changes in the mitochondrial proteome in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin.” Data Brief. (2016) May 20;8:191-5. doi:10.1016/j.dib.2016.05.023

Hwang HJ, Steidemann M, Dunivin TK, Rizzo M, LaPres JJ. “Data of enzymatic activities of the electron transport chain and ATP synthase complexes in mouse hepatoma cells following exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).” Data Brief. (2016) May 20;8:93-7. doi:10.1016/j.dib.2016.05.018

Hwang HJ, Dornbos P, Steidemann M, Dunivin TK, Rizzo M, LaPres JJ. “Mitochondrial-targeted aryl hydrocarbon receptor and the impact of 2,3,7,8-tetrachlorodibenzo-p-dioxin on cellular respiration and the mitochondrial proteome.” Toxicol Appl Pharmacol. (2016) Apr 20. pii: S0041-008X(16)30075-8. doi:10.1016/j.taap.2016.04.005

Saini Y, Proper SP, Dornbos P, Greenwood KK, Kopec AK, Lynn SG, Grier E, Burgoon LD, Zacharewski TR, Thomas RS, Harkema JR, LaPres JJ. “Loss of Hif-2α Rescues the Hif-1α Deletion Phenotype of Neonatal Respiratory Distress In Mice.” PLoS One (2015);10(9):e0139270. doi:10.1371/journal.pone.0139270

Hwang HJ, Lynn SG, Vengellur A, Saini Y, Grier EA, Ferguson-Miller SM, LaPres JJ. “Hypoxia Inducible Factors Modulate Mitochondrial Oxygen Consumption and Transcriptional Regulation of Nuclear-Encoded Electron Transport Chain Genes.” Biochemistry (2015) Jun 23;54(24):3739-48. doi:10.1021/bi5012892

Kaplan BL, Li J, LaPres JJ, Pruett SB, Karmaus PW. “Contributions of nonhematopoietic cells and mediators to immune responses: implications for immunotoxicology.” Toxicol Sci (2015) Jun;145(2):214-32. doi:10.1093/toxsci/kfv060

Tappenden DM, Hwang HJ, Yang L, Thomas RS, Lapres JJ. “The Aryl-Hydrocarbon Receptor Protein Interaction Network (AHR-PIN) as Identified by Tandem Affinity Purification (TAP) and Mass Spectrometry.” J Toxicol (2013);2013:279829. doi:10.1155/2013/279829

Proper SP, Saini Y, Greenwood KK, Bramble LA, Downing NJ, Harkema JR, LaPres JJ. “Loss of hypoxia-inducible factor 2 alpha (HIF2α) in the lung alveolar epithelium of mice leads to enhanced eosinophilic inflammation in cobalt-induced lung injury.” Toxicological Sciences (2013) doi:10.1093/toxsci/kft253.

Greenwood KK, Proper SP, Saini Y, Bramble LA, Jackson-Humbles DN, Wagner JG, Harkema JR, LaPres JJ. “Neonatal epithelial hypoxia inducible factor-1α expression regulates the response of the lung to experimental asthma.” Am J Physiol Lung Cell Mol Physiol (2012) Mar 1;302(5):L455-62. doi:10.1152/ajplung.00193.2011

Vengellur A, Grier E, Lapres JJ. “The Loss of HIF1α Leads to Increased Susceptibility to Cadmium-Chloride-Induced Toxicity in Mouse Embryonic Fibroblasts.” J Toxicol (2011);2011:391074. doi:10.1155/2011/391074

Tappenden DM, Lynn SG, Crawford RB, Lee K, Vengellur A, Kaminski NE, Thomas RS, LaPres JJ. “The aryl hydrocarbon receptor interacts with ATP5α1, a subunit of the ATP synthase complex, and modulates mitochondrial function.” Toxicol Appl Pharmacol (2011) Aug 1;254(3):299-310. doi:10.1016/j.taap.2011.05.004

Sparkenbaugh EM, Saini Y, Greenwood KK, LaPres JJ, Luyendyk JP, Copple BL, Maddox JF, Ganey PE, Roth RA. “The role of hypoxia-inducible factor-1α in acetaminophen hepatotoxicity.” J Pharmacol Exp Ther (2011) Aug;338(2):492-502. doi:10.1124/jpet.111.180521

Patial S, Shahi S, Saini Y, Lee T, Packiriswamy N, Appledorn DM, Lapres JJ, Amalfitano A, Parameswaran N. “G-protein coupled receptor kinase 5 mediates lipopolysaccharide-induced NFκB activation in primary macrophages and modulates inflammation in vivo in mice.” J Cell Physiol (2011) May;226(5):1323-33. doi:10.1002/jcp.22460

Patial S, Saini Y, Parvataneni S, Appledorn DM, Dorn GW 2nd, Lapres JJ, Amalfitano A, Senagore P, Parameswaran N. “Myeloid-specific GPCR kinase-2 negatively regulates NF-κB1p105-ERK pathway and limits endotoxemic shock in mice.” J Cell Physiol (2011) Mar;226(3):627-37. doi:10.1002/jcp.22384

Saini Y, Greenwood KK, Merrill C, Kim KY, Patial S, Parameswaran N, Harkema JR, LaPres JJ. “Acute Cobalt-Induced Lung Injury and the Role of Hypoxia-Inducible Factor 1 in Modulating Inflammation.” Toxicological Sciences 116.2 (2010): 673-81. doi:10.1093/toxsci/kfq155.

Forgacs AL, Burgoon LD, Lynn SG, LaPres JJ, Zacharewski T. “Effects of TCDD on the expression of nuclear encoded mitochondrial genes.” Toxicol Appl Pharmacol (2010) Jul;246(1-2):58-65. doi:10.1016/j.taap.2010.04.006

Saini Y, Kim KY, Lewandowski R, Bramble LA, Harkema JR, Lapres JJ. “Role of hypoxia-inducible factor 1 alpha in modulating cobalt-induced lung inflammation.” Am J Physiol Lung Cell Mol Physiol (2010) Feb;298(2):L139-47. doi:10.1152/ajplung.00252.2009