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Recent Publications

Kaguni JM. “The Macromolecular Machines that Duplicate the Escherichia coli Chromosome as Targets for Drug Discovery.” Antibiotics (Basel). (2018) Mar 14;7:(1). doi: 10.3390/antibiotics7010023

Felczak MM, Chodavarapu S, Kaguni JM. “DnaC, the indispensable companion of DnaB helicase, controls the accessibility of DnaB helicase by primase.” J Biol Chem. (2017) Oct 25. doi: 10.1074/jbc.M117.807644

Kim JS, Nanfara MT, Chodavarapu S, Jin KS, Babu VM, Ghazy MA, Chung S, Kaguni JM, Sutton MD, Cho Y. “Dynamic assembly of Hda and the sliding clamp in the regulation of replication licensing.” Nucleic Acids Res. (2017) Feb 7. doi: 10.1093/nar/gkx081

Chodavarapu S, Kaguni JM. “Replication Initiation in Bacteria.” Enzymes. (2016) Apr 20;39:1-30. doi:10.1016/bs.enz.2016.03.001

Felczak MM, Sage JM, Hupert-Kocurek K, Aykul S, Kaguni JM. “Substitutions of conserved residues in the C-terminal region of DnaC cause thermolability in helicase loading.” J Biol Chem. (2016)Jan 4. doi:10.1074/jbc.M115.708586

Chodavarapu S, Jones AD, Feig M, Kaguni JM. “DnaC traps DnaB as an open ring and remodels the domain that binds primase.” Nucleic Acids Res. (2016)Jan 8;44(1):210-20. doi:10.1093/nar/gkv961

Chodavarapu S, Felczak MM, Simmons LA, Murillo A, Kaguni JM. “Mutant DnaAs of Escherichia coli that are refractory to negative control.” Nucleic Acids Res. (2013)Dec;41(22):10254-67. doi:10.1093/nar/gkt774

Bell SP, Kaguni JM. “Helicase Loading at Chromosomal Origins of Replication.” Cold Spring Harbor Perspectives in Biology (2013);5(6):a010124-a010124. doi:10.1101/cshperspect.a010124.

Felczak MM, Kaguni JM. “The rcbA gene product reduces spontaneous and induced chromosome breaks in Escherichia coli.” J Bacteriol. (2012)May;194(9):2152-64. doi:10.1128/JB.06390-11

Kaguni JM. “Replication initiation at the Escherichia coli chromosomal origin.” Curr Opin Chem Biol. (2011)Oct;15(5):606-13. doi:10.1016/j.cbpa.2011.07.016

Book Chapter
Hupert-Kocurek, Kaguni JM. (2011). "Understanding Protein Function - The Disparity Between Bioinformatics and Molecular Methods" Computational Biology and Applied Bioinformatics, Prof. Heitor Lopes (Ed.), ISBN: 978-953-307-629-4, InTech, Available from:

Kaguni JM "DNA Replication: Initiation in Bacteria." The Encyclopedia of Biological Chemistry, 2e. W.J. Lennarz and M.D. Lane, eds. Elsevier Science pp. 761-766. Link to preview.

Chodavarapu S, Felczak MM, Kaguni JM. “Two forms of ribosomal protein L2 of Escherichia coli that inhibit DnaA in DNA replication.” Nucleic Acids Res. (2011)May;39(10):4180-91. doi:10.1093/nar/gkq1203

Makowska-Grzyska M, Kaguni JM. “Primase directs the release of DnaC from DnaB.” Mol Cell. (2010)Jan 15;37(1):90-101. doi:10.1016/j.molcel.2009.12.031

Felczak MM, Kaguni JM. “DnaAcos hyperinitiates by circumventing regulatory pathways that control the frequency of initiation in Escherichia coli.” Mol Microbiol. (2009)Jun;72(6):1348-63. doi:10.1111/j.1365-2958.2009.06724.x