Recent Publications

Highlighted Publications:

Parent KN, Sinkovits RS, Suhanovsky MM, Teschke CM, Egelman EH, Baker TS. “Cryo-reconstructions of P22 polyheads suggest that phage assembly is nucleated by trimeric interactions among coat proteins.” Phys Biol. (2010) Dec 9;7(4):045004. doi:10.1088/1478-3975/7/4/045004

Teschke CM, Parent KN. “'Let the phage do the work': using the phage P22 coat protein structures as a framework to understand its folding and assembly mutants.” Virology. (2010) Jun 5;401(2):119-30. doi:10.1016/j.virol.2010.02.017

Parent KN, Khayat R, Tu LH, Suhanovsky MM, Cortines JR, Teschke CM, Johnson JE, Baker TS. “P22 coat protein structures reveal a novel mechanism for capsid maturation: stability without auxiliary proteins or chemical crosslinks.” Structure. (2010) Mar 10;18(3):390-401. doi:10.1016/j.str.2009.12.014

Parent KN, Zlotnick A, Teschke CM. “Quantitative analysis of multi-component spherical virus assembly: scaffolding protein contributes to the global stability of phage P22 procapsids.” J Mol Biol. (2006) Jun 16;359(4):1097-106. doi:10.1016/j.jmb.2006.03.068

Parent KN, Doyle SM, Anderson E, Teschke CM. “Electrostatic interactions govern both nucleation and elongation during phage P22 procapsid assembly.” Virology. (2005) Sep 15;340(1):33-45. doi:10.1016/j.virol.2005.06.018

Recent

Bohm K, Porwollik S, Chu W, Dover JA, Gilcrease EB, Casjens SR, McClelland M, Parent KN. “Genes affecting progression of bacteriophage P22 infection in Salmonella identified by transposon and single gene deletion screens.” Mol Microbiol. (2018) Feb 22;. doi: 10.1111/mmi.13936

Parent KN, Schrad JR, Cingolani G. “Breaking Symmetry in Viral Icosahedral Capsids as Seen through the Lenses of X-ray Crystallography and Cryo-Electron Microscopy.” Viruses. (2018) Feb 7;10:(2). doi: 10.3390/v10020067

Doore SM, Schrad JR, Dean WF, Dover JA, Parent KN. “Shigella phages isolated during a dysentery outbreak reveal uncommon structures and broad species diversity” J of Virology (2018) Feb 7. doi: 10.1128/JVI.02117-17

Schrad JR, Young EJ, Abrahão JS, Cortines JR, Parent KN. “Microscopic Characterization of the Brazilian Giant Samba Virus.” Viruses. (2017) Feb 14;9(2). pii: E30. doi: 10.3390/v9020030

Lokareddy RK, Sankhala RS, Roy A, Afonine PV, Motwani T, Teschke CM, Parent KN, Cingolani G. “Portal protein functions akin to a DNA-sensor that couples genome-packaging to icosahedral capsid maturation.” Nat Commun. (2017) Jan 30;8:14310. doi: 10.1038/ncomms14310

Renda BA, Chan C, Parent KN, Barrick JE. “Emergence of a competence reducing filamentous phage from the genome of Acinetobacter baylyi ADP1.” J Bacteriol. (2016) Sep 19. pii: JB.00424-16. doi:10.1128/JB.00424-16

Dover JA, Burmeister AR, Molineux IJ, Parent KN. “Evolved populations of Shigella flexneri phage Sf6 acquire large deletions, altered genomic architecture, and faster life cycles.” Genome Biol Evol. (2016) Aug 6. pii: evw177. doi:10.1093/gbe/evw177

Shi H, Xagoraraki I, Parent KN, Bruening ML, Tarabara VV. “Elution is a critical step for human adenovirus 40 recovery from tap and surface water by crossflow ultrafiltration.” Appl Environ Microbiol. (2016) Jun 10. pii:AEM.00870-16. doi:10.1128/AEM.00870-16

Dong S, Xu T, Zhao P, Parent KN, Chen M. “A Comparison Study of iTEP Nanoparticle-Based CTL Vaccine Carriers Revealed a Surprise Relationship between the Stability and Efficiency of the Carriers.” Theranostics. (2016) 6(5):666-78. doi:10.7150/thno.14068

Cho S, Dong S, Parent KN, Chen M. “Immune-tolerant elastin-like polypeptides (iTEPs) and their application as CTL vaccine carriers.” J Drug Target. (2016) Apr;24(4):328-39. doi:10.3109/1061186X.2015.1077847

Jin Y, Sdao SM, Dover JA, Porcek NB, Knobler CM, Gelbart WM, Parent KN. “Bacteriophage P22 ejects all of its internal proteins before its genome.” Virology. (2015) Nov;485:128-34. doi:10.1016/j.virol.2015.07.006

Porcek NB, Parent KN. “Key residues of S. flexneri OmpA mediate infection by bacteriophage Sf6.” J Mol Biol. (2015) May 22;427(10):1964-76. doi:10.1016/j.jmb.2015.03.012

Janssen ME, Takagi Y, Parent KN, Cardone G, Nibert ML, Baker TS. “Three-dimensional structure of a protozoal double-stranded RNA virus that infects the enteric pathogen Giardia lamblia.” J Virol. (2015) Jan 15;89(2):1182-94. doi:10.1128/JVI.02745-14

Parent KN, Tang J, Cardone G, Gilcrease EB, Janssen ME, Olson NH, Casjens SR, Baker TS. “Three-dimensional reconstructions of the bacteriophage CUS-3 virion reveal a conserved coat protein I-domain but a distinct tailspike receptor-binding domain.” Virology. (2014) Sep;464-465:55-66. doi:10.1016/j.virol.2014.06.017

Pasco V, Shi H, Xagoraraki I, Hashsham SA, Parent KN, Bruening, ML, Tarabara VV. “Polyelectrolyte multilayers as anti-adhesive membrane coatings for virus concentration and recovery.” Journal of Membrane Science. (2014) 469:140-150. doi:10.1016/j.memsci.2014.06.032

Parent KN, Erb ML, Cardone G, Nguyen K, Gilcrease EB, Porcek NB, Pogliano J, Baker TS, Casjens SR. “OmpA and OmpC are critical host factors for bacteriophage Sf6 entry in Shigella.” Mol Microbiol. (2014) Apr;92(1):47-60. doi:10.1111/mmi.12536

Parent KN, Takagi Y, Cardone G, Olson NH, Ericsson M, Yang M, Lee Y, Asara JM, Fichorova RN, Baker TS, Nibert ML. “Structure of a protozoan virus from the human genitourinary parasite Trichomonas vaginalis.” MBio. (2013) Apr 2;4:(2). doi: 10.1128/mBio.00056-13

Parent KN, Deedas CT, Egelman EH, Casjens SR, Baker TS, Teschke CM. “Stepwise molecular display utilizing icosahedral and helical complexes of phage coat and decoration proteins in the development of robust nanoscale display vehicles.” Biomaterials. (2012) Aug;33(22):5628-37. doi: 10.1016/j.biomaterials.2012.04.026

Brodin JD, Ambroggio XI, Tang C, Parent KN, Baker TS, Tezcan FA. “Metal-directed, chemically tunable assembly of one-, two- and three-dimensional crystalline protein arrays.” Nat Chem. (2012) Mar 4;4(5):375-82. doi: 10.1038/nchem.1290

Parent KN, Gilcrease EB, Casjens SR, Baker TS. “Structural evolution of the P22-like phages: comparison of Sf6 and P22 procapsid and virion architectures.” Virology. (2012) Jun 5;427(2):177-88. doi: 10.1016/j.virol.2012.01.040

Yan X, Parent KN, Goodman RP, Tang J, Shou J, Nibert ML, Duncan R, Baker TS. “Virion structure of baboon reovirus, a fusogenic orthoreovirus that lacks an adhesion fiber.” J Virol. (2011) Aug;85(15):7483-95. doi: 10.1128/JVI.00729-11

Parent KN, Sinkovits RS, Suhanovsky MM, Teschke CM, Egelman EH, Baker TS. “Cryo-reconstructions of P22 polyheads suggest that phage assembly is nucleated by trimeric interactions among coat proteins.” Phys Biol. (2010) Dec 9;7(4):045004. doi: 10.1088/1478-3975/7/4/045004

Ng R, Govindasamy L, Gurda BL, McKenna R, Kozyreva OG, Samulski RJ, Parent KN, Baker TS, Agbandje-McKenna M. “Structural characterization of the dual glycan binding adeno-associated virus serotype 6.” J Virol. (2010) Dec;84(24):12945-57. doi: 10.1128/JVI.01235-10

Suhanovsky MM, Parent KN, Dunn SE, Baker TS, Teschke CM. “Determinants of bacteriophage P22 polyhead formation: the role of coat protein flexibility in conformational switching.” Mol Microbiol. (2010) Sep;77(6):1568-82. doi: 10.1111/j.1365-2958.2010.07311.x

Gurda BL, Parent KN, Bladek H, Sinkovits RS, DiMattia MA, Rence C, Castro A, McKenna R, Olson N, Brown K, Baker TS, Agbandje-McKenna M. “Human bocavirus capsid structure: insights into the structural repertoire of the parvoviridae.” J Virol. (2010) Jun;84(12):5880-9. doi: 10.1128/JVI.02719-09

Teschke CM, Parent KN. “'Let the phage do the work': using the phage P22 coat protein structures as a framework to understand its folding and assembly mutants.” Virology. (2010) Jun 5;401(2):119-30. doi: 10.1016/j.virol.2010.02.017

Parent KN, Khayat R, Tu LH, Suhanovsky MM, Cortines JR, Teschke CM, Johnson JE, Baker TS. “P22 coat protein structures reveal a novel mechanism for capsid maturation: stability without auxiliary proteins or chemical crosslinks.” Structure. (2010) Mar 10;18(3):390-401. doi: 10.1016/j.str.2009.12.014

Parent KN, Suhanovsky MM, Teschke CM. “Polyhead formation in phage P22 pinpoints a region in coat protein required for conformational switching.” Mol Microbiol. (2007) Sep;65(5):1300-10. doi: 10.1111/j.1365-2958.2007.05868.x