Recent Publications

Book Chapters

Kaguni LS, Oliveira MT, Tamanoi F. “Preface.” Enzymes. (2016) 39:xi. doi:10.1016/S1874-6047(16)30017-8

Ciesielski GL, Oliveira MT, Kaguni LS. “Chapter Eight - Animal Mitochondrial DNA Replication.” Enzymes. (2016) May 9;39:255-92. doi:10.1016/bs.enz.2016.03.006

Publications

Matsushima Y, Hirofuji Y, Aihara M, Yue S, Uchiumi T, Kaguni LS, Kang D. “Drosophila protease ClpXP specifically degrades DmLRPPRC1 controlling mitochondrial mRNA and translation.” Sci Rep. (2017) Aug 16;7(1):8315. doi:10.1038/s41598-017-08088-6

Morin JA, Cerrón F, Jarillo J, Beltran-Heredia E, Ciesielski GL, Arias-Gonzalez JR, Kaguni LS, Cao FJ, Ibarra B. “DNA synthesis determines the binding mode of the human mitochondrial single-stranded DNA-binding protein.” Nucleic Acids Res. (2017) May 9. doi: 10.1093/nar/gkx395

Nurminen A, Farnum GA, Kaguni LS. “Pathogenicity in POLG syndromes: DNA polymerase gamma pathogenicity prediction server and database.” BBA Clin. (2017) Apr 18;7:147-156. doi: 10.1016/j.bbacli.2017.04.001

Salminen TS, Oliveira MT, Cannino G, Lillsunde P, Jacobs HT, Kaguni LS. “Mitochondrial genotype modulates mtDNA copy number and organismal phenotype in Drosophila. Mitochondrion.” (2017) Feb 15. pii: S1567-7249(16)30075-7. doi: 10.1016/j.mito.2017.02.001

Stiban J, So M, Kaguni LS. “Iron-Sulfur Clusters in Mitochondrial Metabolism: Multifaceted Roles of a Simple Cofactor.” Biochemistry (Mosc). (2016) Oct;81(10):1066-1080. doi: 10.1134/S0006297916100059

Kaguni LS, Oliveira MT. “Structure, function and evolution of the animal mitochondrial replicative DNA helicase.” Crit Rev Biochem Mol Biol. (2016)Jan-Feb;51(1):53-64. doi:10.3109/10409238.2015.1117056

Ciesielski GL, Hytönen VP, Kaguni LS. “Biolayer Interferometry: A Novel Method to Elucidate Protein-Protein and Protein-DNA Interactions in the Mitochondrial DNA Replisome.” Methods Mol Biol. (2016);1351:223-31. doi:10.1007/978-1-4939-3040-1_17

Ciesielski GL, Rosado-Ruiz FA, Kaguni LS. “Purification and Comparative Assay of Human Mitochondrial Single-Stranded DNA-Binding Protein.” Methods Mol Biol. (2016);1351:211-22. doi:10.1007/978-1-4939-3040-1_16

Gajewski JP, Arnold JJ, Salminen TS, Kaguni LS, Cameron CE. “Expression and Purification of Mitochondrial RNA Polymerase and Transcription Factor A from Drosophila melanogaster.” Methods Mol Biol. (2016);1351:199-210. doi:10.1007/978-1-4939-3040-1_15

Rosado-Ruiz FA, So M, Kaguni LS. “Purification and Comparative Assay of the Human Mitochondrial Replicative DNA Helicase.” Methods Mol Biol. (2016);1351:185-98. doi:10.1007/978-1-4939-3040-1_14

Ciesielski GL, Bermek O, Rosado-Ruiz FA, Hovde SL, Neitzke OJ, Griffith JD, Kaguni LS. “Mitochondrial Single-stranded DNA-binding Proteins Stimulate the Activity of DNA Polymerase ? by Organization of the Template DNA.” J Biol Chem. (2015)Nov 27;290(48):28697-707. doi:10.1074/jbc.M115.673707

Oliveira MT, Haukka J, Kaguni LS. “Evolution of the metazoan mitochondrial replicase.” Genome Biol Evol. (2015)Mar 3;7(4):943-59. doi:10.1093/gbe/evv042

Zabalza R, Nurminen A, Kaguni LS, Garesse R, Gallardo ME, Bornstein B. “Co-occurrence of four nucleotide changes associated with an adult mitochondrial ataxia phenotype.” BMC Research Notes (2014);7(1):883. doi:10.1186/1756-0500-7-883.

Baqri RM, Pietron AV, Gokhale RH, Turner BA, Kaguni LS, Shingleton AW, Kunes S, Miller KE. “Mitochondrial chaperone TRAP1 activates the mitochondrial UPR and extends healthspan in Drosophila.” Mech Ageing Dev. (2014)Nov-Dec;141-142:35-45. doi:10.1016/j.mad.2014.09.002

Stiban J, Farnum GA, Hovde SL, Kaguni LS. “The N-terminal domain of the Drosophila mitochondrial replicative DNA helicase contains an iron-sulfur cluster and binds DNA.” J Biol Chem. (2014)Aug 29;289(35):24032-42. doi:10.1074/jbc.M114.587774

Farnum GA, Nurminen A, Kaguni LS. “Mapping 136 pathogenic mutations into functional modules in human DNA polymerase ? establishes predictive genotype-phenotype correlations for the complete spectrum of POLG syndromes.” Biochim Biophys Acta. (2014)Jul;1837(7):1113-21. doi:10.1016/j.bbabio.2014.01.021

Fernández-Moreno MA, Hernández R, Adán C, Roberti M, Bruni F, Polosa PL, Cantatore P, Matsushima Y, Kaguni LS, Garesse R. “Drosophila nuclear factor DREF regulates the expression of the mitochondrial DNA helicase and mitochondrial transcription factor B2 but not the mitochondrial translation factor B1.” Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms (2013);1829(10):1136-46. doi:10.1016/j.bbagrm.2013.07.006.