Recent Publications

Visit Dr. Zacharewski's site for more publications.

Nault R, Doskey CM, Fader KA, Rockwell CE, Zacharewski TR. “Comparison of hepatic NRF2 and AHR binding in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) treated mice demonstrates NRF2-independent PKM2 induction.” Mol Pharmacol. (2018) May 11. doi: 10.1124/mol.118.112144

Fader KA, Nault R, Zhang C, Kumagai K, Harkema JR, Zacharewski TR. “2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-elicited effects on bile acid homeostasis: Alterations in biosynthesis, enterohepatic circulation, and microbial metabolism.” Sci Rep. (2017) Jul 19;7(1):5921. doi: 10.1038/s41598-017-05656-8

Stedtfeld RD, Stedtfeld TM, Fader KA, Williams MR, Bhaduri P, Quensen J, Zacharewski TR, Tiedje JM, Hashsham SA. “TCDD influences reservoir of antibiotic resistance genes in murine gut microbiome.” FEMS Microbiol Ecol. (2017) May 4. doi: 10.1093/femsec/fix058

Nault R, Fader KA, Lydic TA, Zacharewski TR. “Lipidomic evaluation of aryl hydrocarbon receptor-mediated hepatic steatosis in male and female mice by 2,3,7,8-tetrachlorodibenzo-p-dioxin.” Chem Res Toxicol. (2017) Feb 27. doi: 10.1021/acs.chemrestox.6b00430

Fader KA, Nault R, Kirby MP, Markous G, Matthews J, Zacharewski TR. “Convergence of hepcidin deficiency, systemic iron overloading, heme accumulation, and REV-ERBα/β activation in aryl hydrocarbon receptor-elicited hepatotoxicity.” Toxicol Appl Pharmacol. (2017) Feb 14. pii: S0041-008X(17)30064-9. doi: 10.1016/j.taap.2017.02.006

Fader KA, Zacharewski TR. “Beyond the Aryl Hydrocarbon Receptor: Pathway Interactions in the Hepatotoxicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin and Related Compounds.” Curr Opin Toxicol. (2017) Feb;2:36-41. doi: 10.1016/j.cotox.2017.01.010

Kovalova N, Nault R, Crawford R, Zacharewski TR, Kaminski NE. “Comparative analysis of TCDD-induced AhR-mediated gene expression in human, mouse and rat primary B cells.” Toxicol Appl Pharmacol. (2016) Nov 29. pii: S0041-008X(16)30364-7. doi: 10.1016/j.taap.2016.11.009

Nault R, Fader KA, Kopec AK, Harkema JR, Zacharewski TR, Luyendyk JP. “Coagulation-driven hepatic fibrosis requires protease activated receptor-1 (PAR-1) in a mouse model of TCDD-elicited steatohepatitis.” Toxicol Sci. (2016) Sep 9. pii: kfw175. doi:10.1093/toxsci/kfw175

Nault R, Fader KA, Ammendolia DA, Dornbos P, Potter D, Sharratt B, Kumagai K, Harkema JR, Lunt SY, Matthews J, Zacharewski T. “Dose-dependent metabolic reprogramming and differential gene expression in TCDD-elicited hepatic fibrosis.” Toxicol Sci. (2016) Aug 25. pii: kfw163. doi:10.1093/toxsci/kfw163

Joshi N, Kopec AK, Ray JL, Cline-Fedewa H, Nawabi A, Schmitt T, Nault R, Zacharewski TR, Rockwell CE, Flick MJ, Luyendyk JP. “Fibrin deposition following bile duct injury limits fibrosis through an αMβ2-dependent mechanism.” Blood. (2016) Feb 26;. doi:10.1182/blood-2015-09-670703

Nault R, Fader KA, Kirby MP, Ahmed S, Matthews J, Jones AD, Lunt SY, Zacharewski TR. “Pyruvate Kinase Isoform Switching and Hepatic Metabolic Reprogramming by the Environmental Contaminant 2,3,7,8-Tetrachlorodibenzo-p-Dioxin.” Toxicol Sci. (2016) Feb;149(2):358-71. doi:10.1093/toxsci/kfv245

Saini Y, Proper SP, Dornbos P, Greenwood KK, Kopec AK, Lynn SG, Grier E, Burgoon LD, Zacharewski TR, Thomas RS, Harkema JR, LaPres JJ. “Loss of Hif-2α Rescues the Hif-1α Deletion Phenotype of Neonatal Respiratory Distress In Mice.” PLoS One. (2015) 10(9):e0139270. doi:10.1371/journal.pone.0139270

Fader KA, Nault R, Ammendolia DA, Harkema JR, Williams KJ, Crawford RB, Kaminski NE, Potter D, Sharratt B, Zacharewski TR. “2,3,7,8-Tetrachlorodibenzo-p-Dioxin Alters Lipid Metabolism and Depletes Immune Cell Populations in the Jejunum of C57BL/6 Mice.” Toxicol Sci. (2015) Dec;148(2):567-80. doi:10.1093/toxsci/kfv206

Karmaus AL, Zacharewski TR. “Atrazine-Mediated Disruption of Steroidogenesis in BLTK1 Murine Leydig Cells.” Toxicol Sci. (2015) Dec;148(2):544-54. doi:10.1093/toxsci/kfv204

Ong CB, Kumagai K, Brooks PT, Brandenberger C, Lewandowski RP, Jackson-Humbles DN, Nault R, Zacharewski TR, Wagner JG, Harkema JR. “Ozone-Induced Type 2 Immunity in Nasal Airways. Development and Lymphoid Cell Dependence in Mice.” Am J Respir Cell Mol Biol. (2016) Mar;54(3):331-340. doi:10.1165/rcmb.2015-0165OC

Nault R, Colbry D, Brandenberger C, Harkema JR, Zacharewski TR. “Development of a computational high-throughput tool for the quantitative examination of dose-dependent histological features.” Toxicol Pathol. (2015) Apr;43(3):366-75. doi:10.1177/0192623314544379

Kwekel JC, Forgacs AL, Williams KJ, Zacharewski TR. “o-p'-DDT-mediated uterotrophy and gene expression in immature C57BL/6 mice and Sprague-Dawley rats.” Toxicol Appl Pharmacol. (2013) Dec 15;273(3):532-41. doi:10.1016/j.taap.2013.09.024

Nault R, Forgacs AL, Dere E, Zacharewski TR. “Comparisons of differential gene expression elicited by TCDD, PCB126, αNF, or ICZ in mouse hepatoma Hepa1c1c7 cells and C57BL/6 mouse liver.” Toxicol Lett. (2013) Oct 23;223(1):52-9. doi:10.1016/j.toxlet.2013.08.013

Kopec AK, Boverhof DR, Nault R, Harkema JR, Tashiro C, Potter D, Sharratt B, Chittim B, Zacharewski TR. “Toxicogenomic evaluation of long-term hepatic effects of TCDD in immature, ovariectomized C57BL/6 mice.” Toxicol Sci. (2013) Oct;135(2):465-75. doi:10.1093/toxsci/kft156

Kim S, Kiyosawa N, Burgoon LD, Chang CC, Zacharewski TR. “PPARα-mediated responses in human adult liver stem cells: In vivo/in vitro and cross-species comparisons.” J Steroid Biochem Mol Biol. (2013) Nov;138:236-47. doi:10.1016/j.jsbmb.2013.06.004

Forgacs AL, D'Souza ML, Huhtaniemi IT, Rahman NA, Zacharewski TR. “Triazine herbicides and their chlorometabolites alter steroidogenesis in BLTK1 murine Leydig cells.” Toxicol Sci. (2013) Jul;134(1):155-67. doi:10.1093/toxsci/kft096