Vo Lab
Chromatin is the DNA plus the nucleosomes that they wrap around. This is pervasively decorated with chemical modifications called "post-translational modifications (PTMs)".
Our major research goals: We want to understand how chromatin PTMs change during development and adaptation. How do PTMs "choose" their chromatin targets? How do cells balance their PTMs on a genome-wide scale? What happens to cells when "wrong choices" are made? These are all very fundamental questions in the broader area of eukaryotic gene regulation that our team seeks to understand. See Research for more info on current projects in the lab!
Our long-term vision is to understand how chromatin-level gene regulatory programs are formed over a wide variety of life conditions. Our experience with epigenetics/genomics and protein systems biology, along with the superb research environment within the BMB department, primes us for excellence in this area of research. We envision that our work will not only lead to uncovering new biological insights but also significantly advance our understanding of human health and disease.