Research Faculty

Arnosti, David N.
Arnosti, David N.
 Professor
arnosti@msu.edu
Eukaryotic gene regulation, transcriptional activation, and repression in Drosophila; function of retinoblastoma tumor suppressor genes in development.
Benning, Christoph
Benning, Christoph
 Director, Plant Research Laboratory
benning@cns.msu.edu
Biosynthesis of lipids in photosynthetic membranes, lipid trafficking phenomena involving chloroplasts, engineering of crops and algae for biodiesel production.
Chan, Christina
Chan, Christina
 George W. Bissell Professor
krischan@egr.msu.edu
System biology approaches and tissue engineering platforms, reconstructing signaling and gene regulatory networks; understanding how fatty acids are involved in the development of Alzheimer's disease.
DellaPenna, Dean
DellaPenna, Dean
 University Distinguished Professor
dellapen@msu.edu
Biochemical genomics, quantitative genetics and genome wide association mapping of dietary micronutrients in plants. Genomics of medicinal plant metabolism. Synthesis and function of lipid soluble antioxidants in plants.
Dickson, Alex
Dickson, Alex
 Assistant Professor
alexrd@msu.edu
Using computation to elucidate dynamics of drug binding sites; pathways of small-molecule binding and release; development of enhanced sampling algorithms for molecular dynamics; quantitative modeling of chaperone activity in the cell.
Ducat, Daniel
Ducat, Daniel
 Assistant Professor
ducatdan@msu.edu
Molecular and synthetic biology approaches for the study of cyanobacterial core metabolism and redirection of photosynthetic pathways for the production of 'green' fuels and commodity products; mixed cyanobacteria-heterotroph microbial consortia.
Feig, Michael
Feig, Michael
 Professor
feig@msu.edu
Computational modeling of structure and dynamics of proteins and nucleic acids; development of implicit solvent methodologies; multiresolution modeling of supramolecular assemblies.
Ferguson-Miller, Shelagh M.
Ferguson-Miller, Shelagh M.
 University Distinguished Professor
fergus20@msu.edu
Mechanism and regulation of energy transduction in mitochrondria and bacteria; kinetics, mechanics, and protein chemistry of electron transfer and proton transfer in cytochrome c oxidase.
Floer, Monique
Floer, Monique
 Assistant Professor
floer@msu.edu
Analysis of the effects of chromatin architecture on gene expression in cells of the immune system.
Froehlich, John
Froehlich, John

 Research Assistant Professor
froehli5@msu.edu

Garavito, R. Michael
Garavito, R. Michael
 Professor
garavito@msu.edu
Structure and function of membrane proteins; biosynthesis of glycolipids and glycosyltransferase function; protein crystallography.
Grotewold, Erich
Grotewold, Erich
 BMB Chairperson
grotewol@msu.edu
Combinatorial control of flavonoid biosynthesis; Elucidation of the gene regulatory grids in maize and other grasses; Control of Arabidopsis cell cycle by unusual R2R3-MYB factors; Biosynthesis, trafficking, and sequestration of anthocyanins; Metabolic engineering of flavones.
Hamberger, Bjoern
Hamberger, Bjoern
 Assistant Professor
hamberge@msu.edu
Discovery of plant pathways for bioactive diterpenoids found in medicinal plant species.
Hausinger, Robert P.
Hausinger, Robert P.
 Professor
hausinge@msu.edu
Mechanism of enzyme action; structure-function studies of enzymes; incorporation of nickel in bacterial urease; biodegradation of sulfonate compounds; DNA repair; microbial physiology.
He, Jin
He, Jin
 Assistant Professor
hejin1@msu.edu
Epigenetic mechanisms and gene regulation in normal development and diseases.
Hegg, Eric L.
Hegg, Eric L.
 Professor
erichegg@msu.edu
Metalloenzymology; biosynthesis, transport, and regulation of heme and other metal cofactors; mechanism of microbial H2 and N2O production; bioenergy; conversion of biomass to transportation fuels.
Henry, R. William
Henry, R. William
 BMB Associate Chairperson
henryrw@msu.edu
Transcriptional regulation in eukaryotes; functions and architecture of basal transcription machinery; molecular determination of RNA polymerase specificity.
Hoffmann-Benning, Susanne
Hoffmann-Benning, Susanne
 Director, Undergraduate Education
hoffma16@msu.edu
Plant biochemistry; phloem-mediated mechanisms of plant growth and development; identification of factors which regulate plant growth through changes in cell wall and cuticle biosynthesis.
Hong, Heedeok
Hong, Heedeok
 Assistant Professor
honghd@msu.edu
Folding and stability of membrane proteins: chaperone-assisted membrane protein folding, controlled degradation of membrane proteins.
Hoogstraten, Charles G.
Hoogstraten, Charles G.
 Associate Professor
hoogstr3@msu.edu
Biophysical studies of RNA catalysis and RNA-protein interactions; dynamics-function relationships; macromolecular NMR methods and applications; mechanisms and driving forces for tertiary structure formation in RNA.
Howe, Gregg A.
Howe, Gregg A.
 MSU Foundation Professor
howeg@msu.edu
Regulation of plant defense responses; biochemistry of jasmonic acid biosynthesis; plant-insect interactions.
Hsu, Polly
Hsu, Polly
 Assistant Professor
polly.hsu@duke.edu
Using experimental and computational approaches to study genome-wide mRNA translation and identify novel peptides; plant responses under diurnal cycles and environmental stress; circadian rhythms.
Hu, Jian
Hu, Jian
 Assistant Professor
hujian1@msu.edu
Structural and functional studies of membrane proteins crucial in metal homeostasis and vesicle trafficking. Mainly X-ray crystallography, NMR, as well as other biochemical/biophysical approaches.
Jin, Xiangshu
Jin, Xiangshu
 Assistant Professor
jinxiang@msu.edu
Molecular basis of cell-cell communication in development; structural basis for molecular interactions regulating autophagy; structural basis for molecular interactions regulating necrotic cell death.
Jones, A. Daniel
Jones, A. Daniel
 Director, Mass Spec Facility
jonesar4@msu.edu
Biological mass spectrometry and metabolomics of plant stress; plant defense and signaling chemistry involved in plant-insect and plant-pathogen interactions.
Kaguni, Jon M.
Kaguni, Jon M.
 Director, Graduate Education
kaguni@msu.edu
Mechanisms of DNA replication and its regulation in Escherichia coli; nucleic acid-protein interactions.
Kaguni, Laurie S.
Kaguni, Laurie S.
 University Distinguished Professor
lskaguni@msu.edu
Enzymology of mitochondrial DNA replication and transcription; organization and structure of mitochondrial DNA replication origins and promoters; DNA-protein interactions; regulation of DNA and RNA synthesis during Drosophila development.
Kerfeld, Cheryl A.
Kerfeld, Cheryl A.
 Hannah Distinguished Professor
kerfeldc@msu.edu
Structural and functional characterization of bacterial microcompartments and of proteins involved in photoprotection in photosynthetic organisms.
Kramer, David M.
Kramer, David M.
 Hannah Distinguished Professor
kramerd8@msu.edu
Energetics and control of photosynthesis; electron and proton transfer reactions; reactive oxygen generation; understanding the molecular and physiological processes involved in conversion of light energy by plants into forms usable for life; understanding how plants evolved to support life in extreme environments.
Krishnan, Arjun
Krishnan, Arjun
 Assistant Professor
arjun@msu.edu
Computational approaches combining statistics/machine-learning with large-scale genomics/biomedical data for finding mechanistic explanations for how our genome relates to health and disease, specifically as function of age and sex.
Kroos, Lee R.
Kroos, Lee R.
 Professor
kroos@msu.edu
Signaling and gene regulatory mechanisms during bacterial development; intramembrane proteases of Bacillus subtilis; the network governing sporulation during Myxococcus xanthus fruiting body formation.
Kuhn, Leslie A.
Kuhn, Leslie A.
 Professor
kuhnl@msu.edu
Developing computational approaches for protein folding, flexibility, docking, and inhibitor design; integrating computational and experimental approaches.
Kuo, Min-Hao
Kuo, Min-Hao
 Associate Professor
kuom@msu.edu
Modifications and dynamics of chromatin; transcriptional regulation; proteomic interactions involving posttranslational modifications; tumor suppressor protein p53.
Lapidus, Lisa J.
Lapidus, Lisa J.
 Professor
lapidus@msu.edu
Protein folding using optical spectroscopy and microfluidics; dynamics of unfolded proteins; effects of protein aggregation on biological systems (Parkinson's and Alzheimer's diseases).
LaPres, John J.
LaPres, John J.
 Director, BioMolecular Sciences Graduate Studies
lapres@msu.edu
Toxicology of transition metals and environmental pollutants; The role of hypoxia signaling in metal-induced toxicity, development, and cancer.
Last, Robert L.
Last, Robert L.
 Barnett Rosenberg Professor
lastr@msu.edu
Arabidopsis and tomato functional genomics; regulation of plant metabolic pathways for nutritionally important molecules; plant stress tolerance mechanisms; metabolic engineering of plants.
Lunt, Sophia
Lunt, Sophia
 Assistant Professor
sophia@msu.edu
Understanding the role of metabolism in supporting cancer proliferation, heterogeneity, and metastasis.
Martinez-Hackert, Erik
Martinez-Hackert, Erik
 Assistant Professor
emh@msu.edu
Transforming growth factor beta family signaling and regulation in human physiology and disease.
Merz, Kenneth M.
Merz, Kenneth M.
 Director, Institute for Cyber Enabled Research
merzjrke@msu.edu
Research areas include computer-aided drug design (CADD), using the Movable Type method to compute free energies, enthalpies and entropies of biological processes, metalloenzymes and metal ion homeostasis, development and application of linear-scaling quantum mechanical methods to biological problems and NMR and X-ray structure refinement using classical and quantum mechanical methods.
Mias, George I.
Mias, George I.
 Assistant Professor
gmias@msu.edu
Quantitative methods applied to systems medicine studies through the dynamic profiling and integration of multiple omics technologies (e.g. genomics, transcriptomics, proteomics, metabolomics) focusing on applications to personalized medicine and complex disorders (e.g. asthma, leukemia, treatments); modeling of underlying molecular interactions through interdisciplinary dynamic network analyses.
Montgomery, Beronda L.
Montgomery, Beronda L.
 MSU Foundation Professor
montg133@msu.edu
Molecular basis of organ-specific phytochrome responses in higher plants; light-regulated development in cyanobacteria.
Parent, Kristin N.
Parent, Kristin N.
 Assistant Professor
kparent@msu.edu
Biochemical, biophysical and structural biology methods are applied towards an understanding of virus assembly, maturation, and infection processes.
Payankaulam, Sandhya
Payankaulam, Sandhya

 Assistant Professor - Fixed Term
sandhya@msu.edu

Ralston, Amy
Ralston, Amy
 Associate Professor
aralston@msu.edu
Origins and regulations of stem cells during mammalian development, reproduction and fertility, pluripotency.
Sharkey, Thomas D.
Sharkey, Thomas D.
 University Distinguished Professor
tsharkey@msu.edu
Biochemistry and biophysics of processes important in gas exchange between plants and the atmosphere.
Takahashi, Hideki
Takahashi, Hideki
 Associate Professor
htakaha@msu.edu
Molecular mechanisms of nitrogen and sulfur utilization in plants; nutrient sensing, transport and metabolism.
TerAvest, Michaela
TerAvest, Michaela
 Assistant Professor
teraves2@msu.edu
Synthetic biology approaches for optimizing bacterial biofuel production chassis; bacterial respiration and electron transport chains; extracellular electron transfer; microbial electrosynthesis.
Vieille, Claire
Vieille, Claire
 Associate Professor
vieille@msu.edu
Microbial metabolic engineering; determinants of hyperthermophilic protein stability; protein engineering; electricity-driven cofactor recycling.
Walker, Kevin D.
Walker, Kevin D.
 Associate Professor
walke284@msu.edu
Elucidation of biosynthetic pathways of plant-derived products for use (and potential use) as pharmaceuticals, neutraceuticals, and allelochemicals, utilizing an array of methodologies grounded in bioorganic chemistry, organic synthesis, enzymology, molecular genetics, molecular biology, and natural products isolation and characterization (i.e., metabolomics).
Wang, John L.
Wang, John L.
 Director, Medical Education
wangj@msu.edu
Carbohydrate recognition; analysis of carbohydrate-binding proteins in the cell nucleus; nuclear processing and export of mRNA.
Wei, Guowei
Wei, Guowei
 Professor
weig@msu.edu
Mathematical biophysics and molecular biosciences; big data; biomedical/molecular image and surface analysis; quantum kinetic theory.
Weise, Sean
Weise, Sean

 Assistant Professor - Fixed Term
weisesea@msu.edu

Wilkerson, Curtis G.
Wilkerson, Curtis G.
 Director, Proteomics Facility
wilker13@msu.edu
Plant cell wall biosynthesis, discovery of hemicellulose biosynthetic enzymes, transcriptional networks involved in cell wall biosynthesis, and regulation of Golgi processes related to hemicellulose synthesis and secretion.
Yan, Honggao
Yan, Honggao
 Professor
yanh@msu.edu
Protein structure, function, and dynamics; protein engineering; multidimensional multinuclear NMR; 6-hydroxymethyl-7, 8-dihydropteroate pyrophosphokinase; shikimate kinase; cytosine deaminase.
Zacharewski, Timothy R.
Zacharewski, Timothy R.
 Professor
tzachare@msu.edu
Toxicogenomics; receptor-mediated toxicology; endocrine disruption; expression profiling; ligand-induced protein structure.