Recent Publications

Chatterjee, S., and R. P. Hausinger. 2023. Sulfur incorporation into biomolecules: Recent advances. Crit. Rev. Biochem. Molec. Biol. (in press). doi: 10.1080/10409238.2022.2141678.

Gatreddi, S., D. Sui, R. P. Hausinger, and J. Hu. 2023. Irreversible inactivation of lactate racemase by sodium borohydride reveals reactivity of the nickel-pincer nucleotide cofactor. ACS Catalysis (in press). doi: 10.1021/acscatal.2c05461.

Hausinger, R. P. 2023. Inhibition of ureases: Studies and applications. In Ureases: Functions, Classes, and Applications, (Ed. Ligabue-Braun, R., and C. Carlini), Elsevier, (in press).

Hausinger, R. P., J. Hu, and B. Desguin. 2023. The nickel-pincer coenzyme of lactate racemase: A case study of uncovering cofactor structure and biosynthesis. Meth. Enzymol. 685: (in press). doi: 10.1016/bs.mie.2023.03.006.

Chaturvedi, S. S., M. G. Thomas, S. B. J. S. Rifayee, W. White, J. Wildey, C. Warner, C. J. Schofield, J. Hu, R. P. Hausinger, T. G. Karabencheva-Christova, and C. Z. Christov. 2023. Dioxygen binding is controlled by the protein environment in non-heme Fe(II) and 2-oxoglutarate oxygenases – A study on histone demethylase PHF8 and an ethylene forming enzyme. Chem.—Eur. J. (in press). doi: 10.1002/chem.202300138.

Hausinger, R. P. 2023. Five decades of metalloenzymology. The Enzymes 54: (in press). doi: 10.1016/bs.enz.2023.03.001.

Chaturvedi, S. S., S. B. J. S. Rifayee, R. Ramanan, J. A. Rankin, J. Hu, R. P. Hausinger, and C. Z. Christov. 2023. Can an external electric field switch between ethylene formation and L- arginine hydroxylation in the ethylene forming enzyme. Phys. Chem. Chem. Phys. (in press). doi: 10.1039/d3cp01899g

Gatreddi, S., J. Urdiain-Arraiza, B. Desguin, R. P. Hausinger, and J. Hu. 2023. Structural and mutational characterization of a malate racemase from the LarA superfamily. BioMetals. 36:303-313. doi: 10.1007/s10534-022-00372-x. PMC9388697.

Hausinger, R. P. 2022. Microbial metabolism of nickel. In Microbial Metabolism of Metals and Metalloids, (Ed. Hurst, C. J.), Springer. pp. 415-502. doi: 10.1007/978-3-030-97185-4_14.

Turmo, A., J. Hu, and R. P. Hausinger. 2022. Characterization of the nickel-inserting cyclometallase LarC from Moorella thermoacetica and identification of a cytidinylylated reaction intermediate. Metallomics 14:mfac014. doi: 10.1093/mtomcs/mfac014. PMC8962377.

Chatterjee, S., K. F. Parson, B. T. Ruotolo, J. McCracken, J. Hu, and R. P. Hausinger. 2022. Characterization of a [4Fe-4S]-dependent LarE nickel insertase that facilitates nickel-pincer nucleotide cofactor biosynthesis in Thermotoga maritima. J. Biol. Chem. 298:102131. doi: 10.1016/j.jbc.2022.102131. PMC9283937.

Chatterjee, S., S. Gatreddi, S. Gupta, J. L. Nevarez, J. A. Rankin, A. Turmo, J. Hu, and R. P. Hausinger. 2022. Unveiling the mechanisms and biosynthesis of a novel nickel pincer enzyme. Biochem. Soc. Trans. 50:1187-1196. doi: 10.1042/BST20220490. PMC9880988.

McCracken, J., T. M. Casey, and R. P. Hausinger. 2021. 1 H-HYSCORE reveals structural details at the Fe(II) active site of taurine:2-oxoglutarate dioxygenase. Appl. Magn. Resonance, 52:971-994. doi: 10.1007/s00723-020-01288-w. PMC8896577.

Chaturvedi, S. S., R. Rajeev, J. Hu, R. P. Hausinger, and C. Z. Christov. 2021. Atomic and electronic structure determinants distinguish between ethylene formation and L-arginine hydroxylation reaction mechanisms in the ethylene-forming enzyme. ACS Catalysis 11:1578- 1592. doi: 10.1021/acscatal.0c03349.

Rankin, J. A., S. Chatterjee, Z. Tariq, S. Lagishetty, B. Desguin, J. Hu, and R. P. Hausinger. 2021. The LarB carboxylase/hydrolase forms a transient cysteinyl-pyridine intermediate during nickel-pincer nucleotide cofactor biosynthesis. Proc. Natl. Acad. Sci. USA 118:e2106202118. doi: 10.1073/pnas.2106202118. PMC8488589.

Proshlyakov, D. A., M. A. Farrugia, Y. D. Proshlyakov, and R. P. Hausinger. 2021. Iron-containing ureases. Coord. Chem. Rev. 448:214190. doi: 10.1016/j.ccr.2021.214190. PMC8896516.