Recent Publications

Gooding S, Olechnowicz SWZ, Morris EV, Armitage AE, Arezes J, Frost J, Repapi E, Edwards JR, Ashley N, Waugh C, Gray N, Martinez-Hackert E, Lim PJ, Pasricha SR, Knowles H, Mead AJ, Ramasamy K, Drakesmith H, Edwards CM. “Transcriptomic profiling of the myeloma bone-lining niche reveals BMP signalling inhibition to improve bone disease.” Nat Commun. (2019) Oct 4;10(1):4533. doi: 10.1038/s41467-019-12296-1

Aykul S, Martinez-Hackert E. “High-Throughput, Biosensor-Based Approach to Examine Bone Morphogenetic Protein (BMP)-Receptor Interactions.” Methods Mol Biol. (2019) Nov 10;1891:37-49. doi: 10.1007/978-1-4939-8904-1_5

Walker RG, Czepnik M, Goebel EJ, McCoy JC, Vujic A, Cho M, Oh J, Aykul S, Walton KL, Schang G, Bernard DJ, Hinck AP, Harrison CA, Martinez-Hackert E, Wagers AJ, Lee RT, Thompson TB. “Structural basis for potency differences between GDF8 and GDF11.” BMC Biol. (2017) Mar 3;15(1):19. doi: 10.1186/s12915-017-0350-1

Aykul S, Parenti A, Chu KY, Reske J, Floer M, Ralston A, Martinez-Hackert E. “Biochemical and cellular analysis reveals ligand binding specificities, a molecular basis for ligand recognition, and membrane association dependent activities of Cripto-1 and Cryptic.” J Biol Chem. (2017) Jan 26. pii: jbc.M116.747501. doi: 10.1074/jbc.M116.747501

Kempf H, Olmer R, Haase A, Franke A, Bolesani E, Schwanke K, Robles-Diaz D, Coffee M, Göhring G, Dräger G, Pötz O, Joos T, Martinez-Hackert E, Haverich A, Buettner FF, Martin U, Zweigerdt R. “Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells.” Nat Commun. (2016) Dec 9;7:13602. doi: 10.1038/ncomms13602

Aykul S, Martinez-Hackert E. “Determination of half-maximal inhibitory concentration using biosensor-based protein interaction analysis.” Anal Biochem. (2016) Jun 27. pii: S0003-2697(16)30160-9. doi:10.1016/j.ab.2016.06.025

Aykul S, Martinez-Hackert E. “Transforming Growth Factor-β family ligands can function as antagonists by competing for type II receptor binding.” J Biol Chem. (2016) Mar 9;. doi:10.1074/jbc.M115.713487

Aykul S, Martinez-Hackert E. “New Ligand Binding Function of Human Cerberus and Role of Proteolytic Processing in Regulating Ligand-Receptor Interactions and Antagonist Activity.” J Mol Biol. (2016) Feb 13;428(3):590-602. doi:10.1016/j.jmb.2016.01.011

Aykul S, Ni W, Mutatu W, Martinez-Hackert E. “Human Cerberus prevents nodal-receptor binding, inhibits nodal signaling, and suppresses nodal-mediated phenotypes.” PLoS One. (2015) 10(1):e0114954. doi:10.1371/journal.pone.0114954

Achila D, Liu A, Banerjee R, Li Y, Martinez-Hackert E, Zhang JR, Yan H. “Structural determinants of host specificity of complement Factor H recruitment by Streptococcus pneumoniae.” Biochem J. (2015) Jan 15;465(2):325-35. doi:10.1042/BJ20141069

Townson SA, Martinez-Hackert E, Greppi C, Lowden P, Sako D, Liu J, Ucran JA, Liharska K, Underwood KW, Seehra J, Kumar R, Grinberg AV. “Specificity and structure of a high affinity activin receptor-like kinase 1 (ALK1) signaling complex.” J Biol Chem. (2012) Aug 10;287(33):27313-25. doi:10.1074/jbc.M112.377960

Cao Y, Jin X, Huang H, Derebe MG, Levin EJ, Kabaleeswaran V, Pan Y, Punta M, Love J, Weng J, Quick M, Ye S, Kloss B, Bruni R, Martinez-Hackert E, Hendrickson WA, Rost B, Javitch JA, Rajashankar KR, Jiang Y, Zhou M. “Crystal structure of a potassium ion transporter, TrkH.” Nature. (2011) Mar 17;471(7338):336-40. doi:10.1038/nature09731

Martinez-Hackert E, Hendrickson WA. “Structural analysis of protein folding by the long-chain archaeal chaperone FKBP26.” J Mol Biol. (2011) Apr 1;407(3):450-64. doi:10.1016/j.jmb.2011.01.027

Sako D, Grinberg AV, Liu J, Davies MV, Castonguay R, Maniatis S, Andreucci AJ, Pobre EG, Tomkinson KN, Monnell TE, Ucran JA, Martinez-Hackert E, Pearsall RS, Underwood KW, Seehra J, Kumar R. “Characterization of the ligand binding functionality of the extracellular domain of activin receptor type IIb.” J Biol Chem. (2010) Jul 2;285(27):21037-48. doi:10.1074/jbc.M110.114959

Martinez-Hackert E, Hendrickson WA. “Promiscuous substrate recognition in folding and assembly activities of the trigger factor chaperone.” Cell. (2009) Sep 4;138(5):923-34. doi:10.1016/j.cell.2009.07.044

Mareeva T, Martinez-Hackert E, Sykulev Y. “How a T cell receptor-like antibody recognizes major histocompatibility complex-bound peptide.” J Biol Chem. (2008) Oct 24;283(43):29053-9. doi:10.1074/jbc.M804996200

Martinez-Hackert E, Hendrickson WA. “Structures of and interactions between domains of trigger factor from Thermotoga maritima.” Acta Crystallogr D Biol Crystallogr. (2007) Apr;63(Pt 4):536-47. doi:10.1107/S090744490700964X

Lim D, Gregorio GG, Bingman C, Martinez-Hackert E, Hendrickson WA, Goff SP. “Crystal structure of the moloney murine leukemia virus RNase H domain.” J Virol. (2006) Sep;80(17):8379-89. doi:10.1128/JVI.00750-06

Martinez-Hackert E, Anikeeva N, Kalams SA, Walker BD, Hendrickson WA, Sykulev Y. “Structural basis for degenerate recognition of natural HIV peptide variants by cytotoxic lymphocytes.” J Biol Chem. (2006) Jul 21;281(29):20205-12. doi:10.1074/jbc.M601934200

Anikeeva N, Lebedeva T, Krogsgaard M, Tetin SY, Martinez-Hackert E, Kalams SA, Davis MM, Sykulev Y. “Distinct molecular mechanisms account for the specificity of two different T-cell receptors.” Biochemistry. (2003) Apr 29;42(16):4709-16. doi:10.1021/bi026864+